Cellular Mechanism of Mouse Atrial Development
نویسندگان
چکیده
During the development of mammalian heart, left and right atria play an important role in cardiovascular circulation. The embryonic atrium is mainly formed by differentiation progenitor cells proliferation cardiomyocytes, while postnatal primarily shaped increase volume cardiomyocytes. Cell atrial basis for its functions such as “blood reservoir” “supplementary pump”. Deep understanding cellular mechanism imperative to explore causes common congenital arrhythmia heart diseases fibrillation. We used genetically engineered mouse reproduction knowledge, lineage tracing method based on CreloxP system, molecular biology immunofluorescence technology track cardiomyocyte Nppa-GFP line with stereo fluorescence microscope ultra-high-speed confocal microscope. Besides Nppa-CreER; Rosa26 tdTomato was examined during (E10.5 - E18.5) (P0, P3, P5, P7, P14, P28, P8w) stage. Immunofluorescence results revealed that Nppa-positive labeled TNNI3-positive cardiomyocytes protruded into cavity at beginning E11.5 E12.0 subsequent form myocardial trabeculae. Thick comb-shaped myocardium observed after birth, we suspect this particularly normal contractile activity pumping function atrium. Additionally, non-single origin trabecular myocardiocytes were through Tamoxifen-induced experiment. Our findings reveal dynamics non-comprehensive fate decisions produce distinct architecture chamber.
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ژورنال
عنوان ژورنال: Open journal of regenerative medicine
سال: 2022
ISSN: ['2169-2513', '2169-2521']
DOI: https://doi.org/10.4236/ojrm.2022.111001